ESL modeling and system analysis are being used at the conceptual front end of SoC design to improve functional and performance analysis. Similarly, increasing amounts of instrumentation IP and logic-based analysis is being used to facilitate system verification and performance analysis of physical (FPGA and ASIC) implementations. This paper discusses commonalities in requirements, implementation approaches, design flows, and analysis tools at both the ESL and instrumentation-based analysis stages of a design. We present several approaches enabling more common analysis tools and interfaces to allow better-integrated ESL and instrumentation applications for complex chip-level systems analysis.